Programme in printable PDF form.
Doxsey Stephen, Professor, Univ. Massachusetts Medical School, USA
Earnshaw William, Professor, Inst. Cell and Molecular Biology, Univ. Edinburgh, UK
Eichenlaub-Ritter Ursula, Professor, University of Bielefeld, Germany
Gorbsky Gary, Professor and program chair, OMRF, USA
Hardwick Kevin, Principal Investigator, Wellcome Trust Centre for Cell Biol., Univ. Edinburgh, UK
Kallioniemi Olli, Professor, VTT Medical Biotechnology, Finland
Karess Roger, Research Director, CNRS, Centre for Molecular Genetics, France
Maiato Helder, Principal Investigator, Inst. Molecular and Cellular Biology, Univ. Porto, Portugal
Nigg Erich, Director, Dept Cell Biol., Max Plank Inst. Biochemistry, Germany
Sluder Greenfield, Professor, Univ. Massachusetts Medical School, USA
Stukenberg Todd, Associate Professor, Dept. Biochemistry and Molecular Genetics, UVA, USA
Tsao George, Professor, Dept Anatomy, Faculty of Medicine, University of Hong Kong, China
Sunkel Claudio, Professor, Institute for Molecular and Cellular Biology, Portugal
Vallee Richard, Professor, Dept of Pathology, Columbia University, USA
Vaughan Kevin T., Assistant Professor, University of Notre Dame, USA
Wordeman Linda, Professor, University of Washington School of Medicine, USA
Yamamoto Tadashi, Professor, Inst. Medical Science, University of Tokyo, Japan
Yanagida Mitsuhiro, Professor, Dept. Gene Mechanism, Kyoto University, Japan
Saturday 16 June 2007
Arrival in Naantali
- 10:00-16:30 Registration, setting up posters for Poster session, Spa recreational activities
- 17:00 -17:45 Opening keynote lecture. Live analysis of the dynein-LIS1-NudE pathway in brain tissue and cultured cells.
Richard Vallee, Columbia University, New York, USA.
- 18:30-21:00 Welcome reception at Naantali City Hall with Dinner buffet (Bus transport leaves from the front of the Spa Hotel 18:15).
Sunday 17 June 2007
Registration continues 8:00-14:00, setting up posters for Poster session
Session 1: Spindle Assembly Checkpoint Signalling
- 8:00-8:30 Bub1 is essential and maintains centromeric cohesion by activation of the spindle checkpoint. Stephen Taylor, Univ. Manchester, UK.
- 8:30-9:00 Surprising phenotypes of mutations in Mad2 and BubR1: Mitosis in Drosophila doesn’t need the spindle checkpoint, but it does need the kinase activity of BubR1 . Roger Karess, CNRS, Gif-sur-Yvette, France.
- 9:00-9:20 PRP4 is a new spindle assembly checkpoint protein kinase required for MPS1 and MAD2 localization to the kinetochores. Emile Montembault, CNRS, Univ. Rennes, France.
- 9:20-9:40 Identifying the kinetochore-derived “wait anaphase” signal of the mitotic checkpoint. Anita Kulukian, Univ. California at San Diego, USA.
- 9:40-10:00 Coffee/Tea break
Session 2: Spindle assembly checkpoint sub-complexes
- 10:00-10:30 How to build an anaphase inhibitor. Kevin Hardwick, Univ. Edinburgh, UK.
- 10:30-11:00 Centromere/kinetochore mechanism for Cenp-A recruitment and spindle checkpoint protein association. Mitsuhiro Yanagida, Kyoto University, Japan.
- 11:00-11:20 APC/C inhibition and rapid anaphase onset without cytoplasmic amplification. Jagesh Shah, Harv ard Medical School, USA.
- 11:20-11:40 CyclinB1/cyclin-dependent kinase 1 (C DK1) binds the spindle assembly checkpoint (SAC) via MAD1 in a checkpoint independent manner . Mark Jackman, Gurdon Cancer Institute, Cambridge, UK.
- 11:40-12:00 The Mad2 confor mational di mer. Structure and implications for the spindle assembly checkpoint. Marina Mapelli, European Institute of Oncology, Milan, Italy.
- 12:00-13 :00 Lunch
13.00-14.00 Poster session , Exhibitor Floor Show
Session 3: Chromosome Passenger Complex
- 14:00-14:30 Dynamics of Aurora B kinase during oocyte maturation in Xenopus, James Maller, Univ. Colorado School of Medicine, USA.
- 14:30-15:00 Centromeric phosphorylation of histone H3 on threonine-3 converts TD-60 from an inhibitor to an activator of Auro ra B kinase. Todd Stukenberg, Univ. Virginia, USA.
- 15:00-15:30 Inhibition of Incenp impedes anaphase sister chromatid separation and the dynamic flux of chromosomal passenger proteins at inner centromeres. Marko Kallio, VTT Medical Biotechnology and Univ. Turku, Finland.
- 15:30-15:50 Phosphoregulation of Survivin by Aurora-B kinase. Sally Wheatley, Univ. Sussex, UK.
- 15:50-16:10 Coffee/Tea break
Session 4: Polo-like kinase 1
16:10-16:40 PICH: a new Plk1 target with a key role in the spindle assembly checkpoint. Erich Nigg, Max-Planck-Institute for Biochemistry, Martinsried, Germany.
16:40-17:10 Novel Plk1 substrates that control centrosome dynamics. Naoki Oshimori, Univ. Tokyo, Japan.
17:10-17:30 Molecular and structural basis of Plk1 substrate recognition: Implications in subcellular localization. Guillermo de Car cer, CNIO, Spain.
17:30-17:50 Chemical genetics reveals the requirement for Plk1 activity in positioning the RhoA GTPase and triggering cytokinesis in human cells. Prasad Jallepalli, Memorial Sloan-Kettering Cancer Center, USA.
17:50-18:10 Polo-like kinase 1 controls Aurora A kinase function by regulating levels of hBora, Anna Santamaria. Max-Planck-Institute for Biochemistry, Martinsried, Germany.
- 20:00 Dinner at Naantali Spa
Monday 18 June 2007
Session 5: Centrosome and spindle assembly
- 8:10-8:40 TPX2-dependent Aurora-A activation is required for proper spindle assembly in human cells. Alex Bird, Max-Planck-Institute, Dresden, Germany.
- 8:40-9:00 Aurora-A, Plk1 and TPX2: mutual regulation and roles in spindle assembly. Giulia Guarguaglini, Univ. Rome, Italy.
- 9:00-:9:20 TPX2 accumulation is required for progression of meiotic maturation in mouse oocytes . Stephane Brunet, Equipe Physiologie du Developpement, Univ. Paris VI , France.
- 9:20-9:40 Acentrosomal spindle formation in female meiosis . Hiro Ohkura, Univ. Edinburgh, UK.
- 9:40-10:00 Flies with extra centrioles . Renata Basto, Gurdon Cancer Institute, Cambridge, UK.
- 10:00-10:20 Coffee/Tea break
Session 6: Microtubule function and kinetochore interaction
- 10:20-10:50 Regulators of chromosome movement and the mitotic spindle checkpoint . Gary Gorbsky, OMRF, USA.
- 10:50-11:20 Synchronizing chromosome segregation . Helder Maiato, Univ. Porto, Portugal.
- 11:20-11:50 Induction of mitotic dysregulation and chromosomal aberrations by the Epstein Barr Virus encoded LMP1 protein: implication in the pathogenesis of nasopharyngeal carcinoma . George Tsao, Univ. Hong Kong, SAR China.
- 11:50-12:10 Mps1 kinase activity is essential for chromosome alignment by controlling Aurora-B-dependent attachment error-correction . Geert Kops, UMC Utrecht, The Netherlands.
- 12:10- 13 : 10 Lunch
- 13:10-14:00 Poster session , Exhibitor Floor Show
Session 7: Proteomic and genomic tools for mitotic research
- 14:00-14:30 Heterochromatin kills kinetochores: Exploring the epigenetic landscape of the kinetochore with a human artificial chromosome . William Earnshaw, Univ. Edinburgh, UK.
- 14:30-15:00 High-throughput functional and clinical analysis of mitosis-associated kinases in cancer . Olli-P Kallioniemi, VTT Medical Biotechnology, Turku, Finland.
- 15:00-15:20 Proteomic survey of cell division in Drosophila, Pier Paolo D’Avino, Cancer Research UK, Univ. Cambridge, UK.
- 15:20-15:40 Identification of microtubule associated proteins from the early Drosophila embryo – a 21st Centu ry approach . James Wakefield, Univ. Oxford, UK.
- 15:40-16.00 Analysis of mitotic APC/ C complexes by mass spectrometry . Jakob Nilsson, Gurdon Cancer Institute, Cambridge, UK.
- 16:00-16:20 Coffee/Tea break.
- 17:00-21:00 Steam Ship Cruise and Archipelago Dinner (Bus transport leaves from the front of the Spa Hotel 16:40)
Tuesday 19 June 2007
Session 8: Environmental carcinogens and aneuploidy
- 8:20-8:40 Lead chromate induces chromosome instability and decreased expression of key spindle assembly checkpoint proteins . Laura Savery, Univ. Southern Maine, USA.
- 8:40-9:00 S-adenosil-1-methionine counteracts aneuploidy and the mitotic disturbances induced by sodium arsenite . Tzutzuy Ramirez, Univ. Mexico, Mexico.
- 9:00-9:20 Origin of micronuclei in lymphocytes of styrene-exposed reinforced plastic workers and referents . Hannu Norppa, Finnish Institute of Occupational Health, Helsinki, Finland.
- 9:20-9:40 Environmental carcinogens induce chromosome instability through centrosome amplification in human lung cells. Amie Holmes, Univ. Southern Maine, USA.
- 9:40-10:00 Exposure of growing and maturing mouse oocytes in vitro and in vivo to bisphenol A (BPA). Ursula Eichenlaub-Ritter, Univ. Bielefeld, Germany.
- 10 :0 0-10:20 Coffee/Tea break
Session 9: SAC in meiosis
- 10:20-10:50 BubR1 is essential for proper chromosome distribution during meiosis in Drosophila, Claudio Sunkel . Univ. Porto, Portugal.
- 10:50-11:10 Meiotic achiasmatic chromosomes bi-orient in mitotic-like manner . Anna Kouznetsova, Karolinska Institutet, Stockholm, Sweden.
- 11:10-11:40 Relevance of alternations in gene expression and mitochondrial dysfunction for maternal age-related nondisjunction in mammalian oocytes . Ursula Eichenlaub-Ritter, Univ. Bielefeld, Germany.
- 11:40-12:00 Cell cycle progression and chromosome segregation in meiosis I are controlled by the spindle assembly checkpoint in mouse oocytes . Katja Wassmann, CNRS, Univ. Paris VI, France.
- 12 :00 -13 :00 Lunch
- 13:00-14:00 Poster session , Exhibitor Floor show
Session 10: Packing and gluing
- 14 :00-14:20 Centromere chromatin organization in condensin -null cells . Susana Ribeiro, Univ Edinburgh, UK.
- 14 :20-14:40 Does Shugoshin degradation trigger chromosome separation? Anja Hagting, Gurdon Cancer Institute, Cambridge, UK.
- 14:40-15:00 Coordinated regulation of arm and centromeric cohesion by Aurora B . Teresa Rivera, CNIO, Madrid, Spain.
- 15:00-15:20 Displacement and re-accumulation of centromeric cohesion during transient pre-anaphase centromere splitting . Maria Ocampo-Hafalla, Cancer Research UK, London, UK.
- 15 :2 0-15:40 Coffee/Tea break
Session 11: Kinetochore function
- 15:40 -16:00 The human Nup107-160 nuclear pore sub-complex contributes to proper kinetochore functions. Valerie Doye, Institut Curie, CNRS, Paris, France.
- 16 :00 -16:20 Excess of the kinetochore protein Hec1 promotes aberrant chromosome segregation associated with spindle pole defects. Francesca Degrassi, IBPM at Univ. Rome, Italy
- 16:20 -16:40 Mcm21R antagonizes Ch14R/Cenp-H to dynamically modulate kinetochore function in human cells. Patrick Meraldi, Swiss Federal Institute of Technology, Zurich, Switzerland.
- 20:00 Banquet Dinner at Naantali Spa
Wednesday 20 June 2007
Session 12: Cytokinesis
- 8:30-9:00 Centrosomal amplification and spindle multipolarity in cancer cells. William Saunders, Univ. Pittsburgh, USA.
- 9:00-9:20 Calcineurin-mediated dephosphorylation of dynamin II abscission rings completes cytokinesis. Megan Fabbro, Queensland Institute of Medical Research, Brisbane, Australia.
- 9:20-9:40 Mnk1 activity controls abscission by regulating Golgi-derived vesicles at the midbody. Claude Prigent, CNRS, Univ. Rennes, France.
- 9:40-10:00 APCCdh1 plays a role in re-organising the mitotic spindle at anaphase. Catherine Lindon, Univ. Cambridge, Cambridge, UK
- 10:00-10:20 Coffee/Tea break
Session 13: Dynein and kinesins in mitosis
- 10:20-10:50 Cytoplasmic dynein dephoshorylation functions as a molecular switch for the spindle assembly checkpoint. Kevin Vaughan, Univ. Notre Dame, Notre Dame, USA.
- 10:50-11:20 Cytoplasmic dynein light intermediate chain 1 is required for mitotic progression through the spindle assembly checkpoint. Stephen Doxsey, Univ. Massachusetts Medical School, Worcester, USA.
- 11:20-11:50 Regulation of kinetochore function by depolymerising kinesins. Linda Wordeman, Univ. Washington School of Medicine, Seattle, USA.
- 11:50-12:20 Regulation of a kinesin-5 by Drosophila Wee1 kinase. Kristin Garcia, Univ. Colorado, Boulder, USA.
- 12:20-13:20 Lunch
-13:20-14:20 Poster session, Exhibitor Floor Show
Session 14: GTPases in mitosis
- 14:20-14:50 Anillin-mediated targeting of Peanut to pseudocleavage furrows is regulated by Ran. Andrew Wilde, Univ. Toronto, Canada.
- 14:50-15:10 Regulation of the GTPase Tem1 upon spindle mispositioning in budding yeast. Simonetta Piatti, Univ. Milan, Italy.
- 15:10-15:30 Spatial control of mitosis by Ran and importin beta. Patrizia Lavia, CNR-National Research Council, Rome, Italy.
Session 15: Mitosis as pharmaceutical target
- 15:30-16:00 Small molecule targeting of the mitotic spindle checkpoint: a novel concept for anti-cancer therapy. Holger Bastians, Philipps-University Marburg, Germany.
- 16:00-16:20 High-throughput screen for compounds causing a forced mitotic exit identifies a dietary flavonoid. Anna-Leena Salmela, VTT and Univ. Turku, Finland.
- 16:20-16:40 Probing the role of Aurora-kinase activity using chemical genetics. Ellen Ridgway, Univ. Manchester, UK.
- 16:40-16:50: Closing of the scientific sessions
- 16:50-18:30 Coffee/Tea break with General Discussion (Next meeting). End of Poster session.
- 20:00 Farewell Dinner at Naantali Spa